A 32-year-old obese woman presents to her primary care physician’s offi ce for a
preemployment physical. She states that she is in good health, but she has noticed
darkening areas around her axillae and under her breasts. She fi rst noticed the dark
areas a few years ago but has not paid much attention to them. Her family history is
remarkable for obesity, heart disease, hypertension, and type 2 diabetes mellitus. On
physical examination, the patient is a well-appearing but obese female. Her blood
pressure is 135/85 mm Hg, and her heart rate is 80/min. Her body mass index (BMI)
is 32 kg/m2. Examination of the skin shows prominent skin lines in the patient’s axilla, posterior neck, and underneath her breasts. There are also dark, “dirtyappearing,”
velvety plaques in these regions.

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